Withdrawal reactions confirm that the brain of the fetus has
Pregnant Mothers Should Not Take SSRI Antidepressants
canada goose coats on sale THE BLOGThe headlines and the CDC press release were incredibly misleading. In the CDC study, several severe birth defects were doubled or nearly tripled in frequency when SSRIs were taken in the first trimester. canada goose coats on sale
By Peter canada goose clearance R. Contributors control their own work and posted freely to our site. If you need to flag this entry as abusive, send us an email.
By Peter R. “Mom’s Antidepressant Use Poses Little Danger to Baby,” heralded the Atlanta Journal Constitution. “Antidepressants pose low birth defect risk,” claimed Boston Globe. The New York Times ran with the Associated Press’s article titled “Antidepressants Not Big Risk for Defects.” The Wall Street Journal’s coverage was titled “Reassurance on Antidepressants in Pregnancy.” The day before the news stories broke, the Centers for Disease Control spun the news in advance with a press release headlined, “New Study Finds Few Risks of Birth Defects from Antidepressant Use During Pregnancy” (CDC Division of Media, 2007).
The headlines and the CDC press release were incredibly misleading. In the CDC study, several severe birth defects were doubled or nearly tripled in frequency when SSRIs were taken in the first trimester. This combined with the other known toxic effects of SSRIs, including brain damage and dysfunction, make these drugs contraindicated in pregnancy.
canada goose uk black friday SSRI antidepressant use by pregnant mothers in the first trimester of pregnancy have been shown to have previously unidentified links to three birth defects in two new studies reported in the New England Journal of Medicine. One study was associated with the Centers for Disease Control and Prevention (CDC) (Alwan et al., 2007) and the other with Boston University (Louik et al., 2007). canada goose uk black friday
canadian goose jacket The study led by Sura Alwan and colleagues involving the CDC showed the following: “Anencephaly birth without a forebrain showed canada goose deals a 2.4 times greater occurrence in women who had taken SSRIs in the first buy canada goose jacket trimester.” This is a catastrophic, fatal birth defect that is not correctable. canadian goose jacket
The study examined histories of 9622 cases of birth defects and 4092 controls who were infants born without birth defects. Some stillbirths (occurring at 20+ weeks gestation) were included but if anencephaly resulted in a spontaneous miscarriage or a planned abortion, these events would not appear in this study’s Canada Goose sale findings.
canada goose uk shop Omphalocele babies born with organs outside canada goose outlet the body was found to be present 2.8 times as often canada goose black friday sale in the SSRI treated mothers compared to the control group. Some media portrayed this birth defect as a small hernia of the umbilical cord but severity of the condition varies, usually requires surgery as well as weeks to years of adapting, and can be life threatening. canada goose uk shop
canada goose Craniosynostosis the premature closing of one or more sutures or fibrous joints knitting the bones of the infant’s skull showed 2.5 times more prevalence in infants exposed in utero to SSRIs. This condition also varies buy canada goose jacket cheap in severity. It can be primarily a bone condition of the skull or it can be secondary to an underdeveloped brain in the infant. canada goose
Craniosynostosis occurs in about four per 10,000 births according to the National Institutes of Health. babies to be born each year with this birth defect as a result of their mothers taking SSRIs in the first trimester of pregnancy.
cheap canada goose uk In the abstract to the report, the CDC study claimed that it found no association between SSRI use in pregnancy and heart defects in neonates. However, that’s not true. The study found that obese women who did not use SSRIs had an increased risk with heart defects and that obese women who did use SSRIs had an even greater risk of neonatal heart defects with an adjusted odds ratio of 5.9 (95% CI, 2.4 14.3)! cheap canada goose uk
uk canada goose outlet The second study by Carol Louik and her colleagues did not find an overall correlation between SSRI use and the two defects, craniosynostosis and omphalocele. It did however find an association between sertraline (Zoloft) and both omphalocele and septal defects in the heart, and between paroxetine (Paxil) and right ventricular outflow tract obstruction defects of the heart. uk canada goose outlet
Louik made many statements to the press reassuring people, in effect, not to worry. She made no mention of other birth defects and neonatal problems associated with SSRI antidepressants. Her study had funding from two pharmaceutical companies, including GlaxoSmithKline, the manufacturer of Paxil (Seward, 2007), one of the most implicated antidepressants in regard to birth defects. The company’s money was well spent. Thanks in part to Louik’s highly publicized comments, headlines throughout the country played down the risk.
canada goose factory sale Nor are these the only birth defects related to SSRI consumption during pregnancy. In December of 2005, the FDA issued a Public Health Advisory warning that the risk of congenital malformation, especially canada goose store of the heart, was increased by the consumption of Paxil in the first trimester of pregnancy. The American College of Obstetricians and Gynecologists (ACOG) (2006) warned pregnant women to avoid taking Paxil and also showed concern about any antidepressant exposure during pregnancy. Yet the CDC and researchers are using the new studies to exonerate SSRIs. This is clearly an orchestrated attempt to reassure the public https://www.pick-canadagoose.com after the FDA’s and ACOG’s earlier warnings. canada goose factory sale
buy canada goose jacket cheap The 2007 CDC study offers an illuminating discussion of other study findings concerning abnormal in utero development, including delayed ossification (bone development). “A specific role of serotonin in cardiac and craniofacial morphogenesis in the rodent embryo has also been established,” according to Alwan, et al. (2007) in the CDC study. buy canada goose jacket cheap
uk canada goose Newborns also go through withdrawal when their mothers have taken antidepressants during pregnancy. One study found a rate of 30% in neonates exposed in utero to SSRIs (Levinson Castiel et al., 2006). Withdrawal symptoms in infants reported in various studies include irritability, high pitched or weak crying, tremors, poor muscle tone, disturbed sleep, rapid breathing and respiratory distress, and increased admissions to the neonatal intensive care unit. uk canada goose
In addition, children exposed in utero to SSRIs have an increased risk of developing persistent pulmonary hypertension at birth. This disorder, which is estimated to occur in one or two infants for every 1000 live births, will occur six times more frequently in children exposed to SSRIs after the twentieth week of pregnancy. The disorder causes “significant morbidity and mortality” (Food and Drug Administration, 2006). These children have difficulty getting enough oxygen into their lungs. The two recent studies in the New England Journal of Medicine limited themselves to SSRI exposure during the first trimester; but the neonatal pulmonary hypertension studies show that some hazards will develop during exposure later in pregnancy. Again, the CDC and the researchers drew no attention to these hazards.
Withdrawal reactions confirm further potentially disastrous consequences of SSRIs to neonates that the CDC and the researchers failed to consider in their reassuring statements. Withdrawal reactions confirm that the brain of the fetus has been bathed in SSRIs and that is has suffered significant functional changes. It should be no surprise that it is not good to bath the growing brain in toxic drugs like SSRIs. Serotonin is intimately involved in the development of the brain in utero and SSRIs inhibit normal brain cell development (Norrholm and Ouimet, 2000). It is also known that SSRIs cause myriad toxic effects on neurons in living animals, causing brain cells to grow canada goose coats abnormally (Wegerer et al., 1999; Kalia et al., 2000). Unavoidably, similar effects must be taking place in the human fetus exposed to SSRIs. In addition, the SSRIs cause drastic biochemical imbalances in the brain, many of them persistent or permanent. At present we have no way of measuring the harmful impact on the growing brain and the future mind of the fetus; but exposure to SSRIs is bound to be harmful in the long run.
Also alarming is the Wall Street Journal report that antidepressant use during pregnancy has jumped from 5.7% in1999 to 13.4% in 2003 (Seward, 2007). The data was based on Medicaid patients and could be higher for the general population.
Canada Goose Jackets The reassuring attitude promoted in the CDC’s press release flew in the face of evidence linking SSRI exposure during pregnancy to increased birth defects, and the additional evidence of SSRI toxicity in the developing brain. It cheap Canada Goose proclaimed that the study “found no significant increase in the risks for the majority of birth defects assessed.” But I’ve never heard of any prescribed drug that increases birth defects “for the majority of birth defects.” The assertion was sheer nonsense, carefully calculated to mislead and obfuscate. Canada Goose Jackets
canada goose clearance Women and their doctors who only catch the headlines created by these studies are being grossly misled. SSRIs should never be used during pregnancy. canada goose clearance
buy canada goose jacket Drug advocates, including the CDC, justify the use Canada Goose online of SSRIs during pregnancy on the basis that depression has its own hazards. But these hazards pale in comparison to the upheaval that will befall new mothers, fathers and the extended families of the children who are born with profound birth defects. buy canada goose jacket
Canada Goose Parka The worst hazards of depression in pregnancy are those of suicidality and, very rarely, infanticide. But the SSRIs are implicated in increasing the risks of both suicide and violence (Breggin, 2001, 2003; Breggin and Breggin, 1994). In fact, the new FDA labels for antidepressants specifically warn about SSRI induced suicidality in youth and in young adults, the very group most likely to become pregnant (Food and Drug Administration, 2007). Now we know that the SSRIs not only threaten to cause the death of the mother through suicide but the death of the child as well through lethal birth defects. But doctors will have read the headlines inspired by the CDC, and imagine there is little risk. Furthermore, few physicians realize that meta analyses canada goose coats on sale have canada goose clearance sale shown that antidepressants work no better than placebo Canada Goose Jackets at lifting depression (Kirsch et al., 2002; Moncrieff and Kirsch, 2005). The risk/benefit ration weighs a placebo effect against increased parental suicide and violence, and babies with congenital defects, babies undergoing withdrawal reactions, and babies whose brains have been forever changed by being soaked in SSRIs during their development. Canada Goose Parka
Canada Goose online There are many approaches to helping depressed people without resort to drugs (Breggin, 2001; Breggin and Breggin, 1994). Exercise has proven effective in alleviating depression. Therapy and counseling can also be very helpful, and in the case of pregnant women, family therapy involving the father of the child and other family members can be especially supportive. Pregnant mothers need to stay in touch with other mothers to be or to form an informal support group, and they need to plan canada goose ahead for as much emotional support as they can find for several months or more after giving birth. Anticipating help Canada Goose Outlet and support after the birth is one of the best antidotes to depression during the pregnancy Canada Goose online.