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In controlled clinical trials8.8of patients treated with XENICAL discontinued treatment due to adverse eventscompared with 5.0of placebo-treated patientsFor XENICALthe most common adverse events resulting in discontinuation of treatment were gastrointestinal.
Distributed byGenentech USAIncA Member of the Roche Group1 DNA WaySouth San FranciscoCA 94080-4990RevisedAug 2016.
Xenical is only part of a complete program of treatment that also includes dietexerciseand weight controlYour daily intake . of fatproteinand carbohydrates should be evenly divided over all of your daily mealsFollow your dietmedicationand exercise routines very closely.
In generalthe first occurrence of these events was within 3 months of starting therapyOverallapproximately 50of all episodes of GI adverse events associated with XENICAL treatment lasted for less than 1 weekand a majority lasted for no more than 4 weeksHoweverGI adverse events may occur in some individuals over a period of 6 months or longer.
Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotenesee DOSAGE AND ADMINISTRATIONand ADVERSE REACTIONSIn additionthe levels of vitamin D and beta-carotene may be low in obese patients compared with non-obese subjectsThe supplement should be taken once a day at least 2 hours before or after the administration of XENICALsuch as at bedtime.
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