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In a rat developmental toxicity studyoral administration of 1000 mg cilostazol/kg/day was associated with decreased fetal weightsand increased incidences of cardiovascularrenaland skeletal anomaliesventricular septalaortic arch and subclavian artery abnormalitiesrenal pelvic dilation14 th riband retarded ossificationAt this dosesystemic exposure to unbound cilostazol in nonpregnant rats was about 5 times the exposure in humans given the MRHDIncreased incidences of ventricular septal defect and retarded ossification were also noted at 150 mg/kg/day5 times the MRHD on a systemic exposure basisIn a rabbit developmental toxicity studyan increased incidence of retardation of ossification of the sternum was seen at doses as low as 150 mg/kg/dayIn nonpregnant . rabbits given 150 mg/kg/dayexposure to unbound cilostazol was considerably lower than that seen in humans given the MRHDand exposure to 3,4-dehydro-cilostazol was barely detectable.

Your symptoms may improve in 2-4 weeksbut it . may take up to 12 weeks before you get the full benefit of this drug.

Call your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

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