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This drug can increase the sedating effects of other medications that cause sedationSuch drugs include:

There is no specific antidote for clonidine overdosageClonidine overdosage may result in the rapid development of CNS depressionthereforeinduction of vomiting buy clonidine 0.1/24 dis ipecac syrup buy clonidine 0.1/24 dis not recommendedGastric lavage may be indicated following recent and/or large ingestionsAdministration of activated charcoal and/or a cathartic may be beneficialSupportive care may include atropine sulfate for bradycardiaintravenous fluids and/or vasopressor agents for hypotension and vasodilators for hypertensionNaloxone may be a useful adjunct for the management of clonidine-induced respiratory depressionhypotension and/or comablood pressure should be monitored since the administration of naloxone has occasionally resulted in paradoxical hypertensionDialysis is not likely to significantly enhance the elimination of clonidine.

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if surgery requires discontinuation, administer parenteral antihypertensive therapy as necessary, and resume clonidine therapy as soon as possible.