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the mice were administered the trans and racemic forms of tamoxifen for 13 to 15 months at doses of 5, 20 and 50 mg kg day about one-half, two and five-fold the daily recommended human dose on a mg m 2 basis .
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9 years, including blinded follow-up on 8,306 women with an intact uterus at randomization in the nsabp p-1 risk reduction trial, the incidence of both adenocarcinomas and rare uterine sarcomas was increased in women taking tamoxifen.
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in 2006, the large star clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up, although the difference was not statistically significant, there were 36 fewer uterine cancers and 29 fewer blood clots in women taking raloxifene than in women taking tamoxifen.
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also, it has not been satisfactorily explained to me how tamoxifen affects ovulation and menstruation.
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