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An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentanTherefore concomitant administration of MICRONASE and bosentan is contraindicated.

Glyburide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreasan effect dependent upon functioning beta cells in the pancreatic isletsThe mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly establishedWith chronic administration in Type II diabetic patientsthe blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drugExtrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugsThe combination of glyburide and metformin may have a synergistic effectsince both agents act to improve glucose tolerance by different but complementary mechanisms.

Foods that help maintain good blood sugar levels are foods that are low on the glycemic indexfor example:

Eating a lot of foods and drinking beverages with simple carbohydratespizzawhite breadspastascerealspastriesetcand simple sugarsdonutscandyetc

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