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Heart and blood pressure medications diltiazem cardizem, tiazac , nicardipine cardene , verapamil calan, covera-hs, isoptin, verelan , potassium sparing diuretics amiloride midamor , spironolactone aldactone and triamterene dyrenium cholesterol lowering medications lovastatin mevacor and simvastatin zocor antibiotics and antifungals clarithromycin biaxin , erythromycin, naficillin, fluconazole diflucan , intraconazole sporanox , ketoconazole nizoral , and rifampin rifadin, rimactane anti-seizure anti-epileptic medications carbamazepine tegretol , phenobarbital solfoton , and phenytoin dilantin antidepressants nefazadone serzone and the selective serotonin reuptake inhibitors ssris such as paroxitine paxil , fluoxetine prozac , and sertraline zoloft human immunodeficiency virus hiv protease inhibitors indinivir crixivan , saquinavir fortovase, invirase , ritonavir norvir , and nelfinavir viracept others allopurinol lopurin, zyloprim , bromocryptine parlodel , androgens male hormones , estrogens female hormones , danazol danocrine , metoclopramide reglan , methylprednisolone, octreotide, ticlopidine ticlid , cimetidine tagamet , methoxsalen oxsoralen , coal tar balnetar, zetar , trioxsalen trisoralen be sure to tell your doctor if you are taking any of these medications.

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Renal impairment affects the clearance of metoclopramideIn a study with patients with varying degrees of renal impairmenta reduction in creatinine clearance was correlated with a reduction in plasma clearancerenal clearancenon-renal clearanceand increase in elimination half-lifeThe kinetics of metoclopramide in the presence of renal impairment remained linear howeverThe reduction in clearance as a result of renal impairment suggests that adjustment downward of maintenance dosage should be done to avoid drug accumulation.

Rare occurrences of neuroleptic malignant syndromeNMShave been reportedThis potentially fatal syndrome is comprised of the symptom complex of hyperthermiaaltered consciousnessmuscular rigidityand autonomic dysfunctionsee WARNINGS

The safety profile of metoclopramide in adults cannot be extrapolated to pediatric patientsDystonias and other extrapyramidal reactions associated with metoclopramide are more common in the pediatric population than in adultsSee WARNINGS and ADVERSE REACTIONSExtrapyramidal Reactions

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