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Ergotamineergot derivativesincluding methysergideother 5-HT 1B/1D receptor agonistsDue to an additive effectthe concomitant use of rizatriptan and ergotamineergot derivativesincluding methysergideor other 5-HT 1B/1D receptor agonistse.gsumatriptanzolmitriptannaratriptanincrease the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contra-indicatedsee section 4.3
Monoamine oxidase inhibitorsRizatriptan is principally metabolised via monoamine oxidaseAsubtypeMAO-APlasma concentrations of rizatriptan and its active N-monodesmethyl metabolite were increased by concomitant administration of a selectivereversible MAO-A inhibitorSimilar or greater effects are expected with non-selectivereversiblee.glinezolidand irreversible MAO inhibitorsDue to a risk of coronary artery vasoconstriction and hypertensive episodesadministration of MAXALT to patients taking inhibitors of MAO is contraindicatedsee section 4.3
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