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Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia.

1Accelerated prothrombin timepartial thromboplastin timeand platelet aggregation timeincreased platelet countincreased factors IIVII antigenVIII antigenVIII coagulant activityIXXXIIVII-X complexII-VII-X complexand beta-thromboglobulindecreased levels of anti-factor Xa and antithrombin IIIdecreased antithrombin III activityincreased levels of fibrinogen and fibrinogen activityincreased plasminogen antigen and activity2Increased thyroid-binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT 4 levelsby column or by radioimmunoassayor T 3 levels by radioimmunoassayT 3 resin uptake is decreasedreflecting the elevated TBGFree T 4 and free T 3 concentrations are unalteredPatients on thyroid replacement therapy may require higher doses of thyroid hormone3Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroids and sex steroidsrespectivelyFree hormone concentrations may be decreasedOther plasma proteins may be increasedangiotensinogen/renin substratealpha-1-antitrypsinceruloplasmin4Increased plasma HDL and HDL 2 subfraction concentrationsreduced LDL cholesterol concentrationincreased triglycerides levels5Impaired glucose tolerance6Reduced response to metyrapone test.

15Crane MGHarris JJWinsor W 3dHypertensionoral contraceptive agentsand conjugated estrogensAnn Intern Med 74197113-21.

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flowbreakthrough bleedingspottingdysmenorrhea.

40Aldinger KBen-Menachem YWhalen GFocal nodular hyperplasia of the liver associated with high-dosage estrogensArch Intern Med 1371977357-9.

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