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Th ats p hundd patint-yas conimd complicatd and uncomplicatd upp GI clinical vnts (poations, ulcs and blds (PUBs)) w 0.67 (95% CI 0.57, 0.77) with toicoxib and 0.97 (95% CI 0.85, 1.10) with diclonac, yilding a lativ isk 0.69 (95% CI 0.57, 0.83).

Acoxia is not appovd in th U.S. bcaus concns about cadiovascula isks associatd with slctiv COX-2 inhibitos. COX-2 inhibitos can incas blood pssu and may damag th lining blood vssls, incasing th isk stoks and hat attacks.

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en el otro estudio, las dosis de 120 mg de arcoxia aumentaron 28el abc y disminuyeron 13 la depuraci n renal del metotrexato.