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Discontinuation of Plavix increases the . risk of cardiovascular eventsIf Plavix must be temporarily discontinuede.gto treat bleeding or for surgery with a major risk of bleedingrestart it as soon as possibleWhen possibleinterrupt therapy with Plavix for five days prior to such surgeryResume Plavix as soon as hemostasis is achieved.

This medicine is not expected to harm an unborn babyTell your doctor if you are pregnant.

The use of Plavix in CURE was associated with a decrease in the use of thrombolytic therapy71 patients1.1in the Plavix group126 patients2.0in the placebo grouprelative risk reduction . of 43and GPIIb/IIIa inhibitors369 patients5.9in the Plavix group454 patients7.2in the placebo grouprelative risk reduction of 18The use of Plavix in CURE did not affect the number of patients treated with CABG or PCIwith or without stenting2253 patients36.0in the Plavix group2324 patients36.9in the placebo grouprelative risk reduction of 4.0

Plavix is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

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