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Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indicationsboth psychiatric and nonpsychiatricshould be alerted about the need to monitor patients for the emergence of agitationirritabilityunusual changes in behaviorand the other symptoms described aboveas well as the emergence of suicidalityand to report such symptoms immediately to lexapro generalized anxiety disorder care providersSuch monitoring should include daily observation by families and caregiverssee PATIENT INFORMATIONPrescriptions for Lexapro should be written for the smallest quantity of tablets consistent with good patient managementin order to reduce the risk of lexapro generalized anxiety disorder.
Lexapro oral solution containsescitalopram oxalate equivalent to 1 mg/mL escitalopram baseIt also contains the following inactive ingredientssorbitolpurified watercitric acidsodium citratemalic acidglycerinpropylene glycolmethylparabenpropylparabenand natural peppermint flavor.
Escitalopram is metabolized to S-DCT and S-lexapro generalized anxiety disorder-DDCTIn humansunchanged escitalopram is the predominant compound in plasmaAt steady statethe concentration of the escitalopram metabolite S-DCT in plasma is approximately one-third that of escitalopramThe level of S-DDCT was not detectable in most subjectsIn vitro studies show that escitalopram is at least 7 and 27 times more potent than S-DCT and S-DDCTrespectivelyin the inhibition of serotonin reuptakesuggesting that the metabolites of escitalopram do not contribute significantly to the antidepressant actions of escitalopramS-DCT and S-DDCT also have no or very low affinity for serotonergic5-HT 1-7or other receptors including alphaand beta-adrenergicdopamineD 1-5histamineH 1-3muscarinicM 1-5and benzodiazepine receptorsS-DCT and S-DDCT also do not bind to various ion channels including NaKCl and Cachannels.
Because psychoactive drugs may impair judgmentthinkingor motor skillspatients should be cautioned about operating hazardous machineryincluding automobilesuntil they are reasonably certain that Lexapro therapy does not affect their ability to engage in such activities.
Side effects have been reported to be generally mild and transientThey are most common during the first 2 weeks of treatment and decrease in intensity and . frequency with continued treatmentThey generally do not lead to treatment cessation.
There have been rare postmarketing reports describing patients with weaknesshyperreflexiaand incoordination following the use of an SSRI and sumatriptanIf concomitant treatment . with sumatriptan and an SSRIe.gfluoxetinefluvoxamineparoxetinesertralinecitalopramescitalopramis clinically warrantedappropriate observation of the patient is advised.
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the fda approved today the first generic version of the antidepressant escitalopram lexapro .