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When prescribing colchicine, i agree that there should be follow-up and a good discussion of its side effect profile.
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Taking certain medicines with colchicine capsules can cause your level of colchicine to be too highespecially if you have kidney or liver problemsTell your healthcare provider about all your medical conditionsincluding if you have kidney or liver problemsYour dose of colchicine capsules may need to be changedEven colchicine price that you take for a short period of timesuch as antibioticscan interact with colchicine capsules and cause serious side effects or death.
Read the Medication Guide provided by your pharmacist before you start taking colchicine and each time you get a refillIf you have any questions regarding the informationask your doctor or pharmacist.
This medication is used to prevent or treat gout attacksflaresUsually gout symptoms develop suddenly and involve only one or a few jointsThe big toekneeor ankle joints are most often affectedGout is caused by too much uric acid in the bloodWhen uric acid levels in the blood are too highthe uric acid may form hard crystals in your jointsColchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint(s
Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both Colchicine price-glycoprotein and CYP3A4 inhibitorsSee DRUG INTERACTIONSCombining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.
The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal colchicine price significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be colchicine price by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics
If a dose of colchicine capsules is missedadvise the patient to take the dose as soon as possible and then return to the normal dosing scheduleHoweverif a dose is skippedthe patient should not double the next dose.
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colchicine tablets are manufactured by actavis and are used to prevent gout flare-ups.