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Food does not have a clinically significant effect on dapoxetine pharmacokineticsMean maximal plasma concentrations of dapoxetine decrease slightly after a high-fat mealfrom 443 ng/mlfastedto 398 ng/mlfedand azitromicin order. are delayed by approximately 0.5 h following a high-fat meal1.30 h fasted1.83 h fedDresser et al2006bThe rate of absorption is modestly decreasedbut there is no effect of food on the elimination of dapoxetine or the exposure to dapoxetineas assessed by the plasma concentration versu s time AUCThe frequency of nausea is decreased after a high-fat meal247/29of fasted subjects and 144/29of fed subjects respectively

The stop-start technique has since been popularized by Kaplan in 1983In this technique the man is asked to pause during sexual stimulationjust prior to impending ejaculationThis pause allows the patient to acclimatize to the sensation and to condition himself to increased ejaculatory controlThis technique helps the patient to heighten his awareness of sexual sensationsUnfortunatelymany others have found that any initial success achieved by behavioral therapy was not maintained at 3-year follow-upSharlip 2005Non-pharmacological treatment options for PE are provided in Figure 1

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