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A greater incidence of dyskinesias was seen with sinemet cr than with sinemet .

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A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Tablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.3.

The addition of carbidopa with levodopa in the form of SINEMET reduces the peripheral effectsnauseavomitingdue to decarboxylation of levodopahowevercarbidopa does not decrease the adverse reactions due to the central effects of levodopaBecause carbidopa permits more levodopa to reach the brain and more dopamine to be formedcertain adverse central nervous systemCNSeffectse.gdyskinesiasinvoluntary movementsmay occur at lower dosages and sooner with SINEMET than with levodopa alone.

NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermiaNeurological findingsincluding muscle rigidityinvoluntary movementsaltered consciousnessmental status changesother disturbancessuch as autonomic dysfunctiontachycardiatachypneasweatinghyperor hypotensionlaboratory findingssuch as creatine phosphokinase elevationleukocytosismyoglobinuriaand increased serum myoglobin have been reported.

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if sinemet sr is discontinued, the dose should be tapered to reducethe risk of hyperpyrexia and confusion.