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The concomitant use of procyclidine with some neuroleptics for the treatment of extrapyramidal symptoms has been associated with a reduction in neuroleptic plasma concentrationsHowever this reduction is unlikely to be associated with a significant reduction in clinical effect.

Patients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Kemadrin is also indicated for the control of extrapyramidal symptoms induced by neuroleptic drugs including pseudo-parkinsonismacute dystonic reactions and akathisia.

In a proportion of patients undergoing neuroleptic treatmenttardive dysknesias will occurWhile anticholinergic agents do not cause this syndromewhen given in combination with neuroleptics they may exacerbate the symptoms of tardive dyskinesia or reduce the threshold at which these symptoms appear in predisposed patientsIn such individuals subsequent adjustment of neuroleptic therapy or reduction in anticholinergic treatment should be considered.

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