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Interstitial pneumonitis has been reported as part of the postmarketing experienceInterstitial pulmonary fibrosis has been reported in patients receiving high doses of cyclophosphamide over a prolonged period.

Cytoxanalthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugsThe following malignancies are often susceptible to Cytoxan treatment:

Cyclophosphamide for InjectionUSPlyophilized powderis a sterile white cake containing cyclophosphamide and mannitol and is supplied in vials for single . dose use.

Thrombocytopenia or anemia develop occasionally in patients treated with CytoxanThese hematologic effects usually can be reversed by reducing the drug dose or by interrupting treatmentRecovery from leukopenia usually begins in 7 to 10 days after cessation of therapy.

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