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But no randomized, controlled trial has evaluated the long-term risk of serious liver problems with any of the topical forms of diclofenac.

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Information about Diclofenac.

In addition to this reviewthe TGA has also completed a full safety review of diclofenac.

This medicine is available from a pharmacist and requires a prescriptionIt is Schedule 4Prescription Only Medicineopen tool tip to find out more.

All eight NSAIDs are available on prescriptionwhile diclofenacnaproxen and ibuprofen are also . availablein lower dose over-the-counterOTCforms that can be obtained without a prescriptionPiroxicam is also available as an OTC topical medicine

In summarywhile use of NSAIDs at prescription-only dosages was already known to increase the risk of high blood pressureheart failureheart attack and strokethe TGA NSAIDs review found that these risks also applied to OTC forms of diclofenacnaproxen and ibuprofen.

The TGA has developed four options to reduce the risks associated with OTC NSAIDs and is currently undertaking public consultation regarding these alternatives.

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hepatic impairment no dedicated diclofenac pharmacokinetics studies in patients with hepatic impairment were conducted.