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Avoid concomitant use of plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of plavix see drug interactions .

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If you need surgery or dental worktell the surgeon or dentist ahead of time that you take Plavix.

In a small study comparing men and womenless inhibition of ADP-induced platelet aggregation was observed in women.

In CAPRIEwhich compared Plavix to aspirinpruritus was more frequently reported in those taking PlavixNo other difference in the rate of adverse eventsother than bleedingwas reported.

Clopidogrel is an inhibitor of platelet activation and aggregation through the . irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.

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several large clinical trials have demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel plavix .