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Nausea can be severeVomitinganorexiametallic tasteabdominal discomfortdiarrhoea and weight loss are also commonHepatotoxicity is reported in about 2of patients taking the drugNervous system toxicity may be responsive to niacin or pyridoxinesee Appendix 2
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Gastrointestinal intolerance is by far the major problem with ethionamidenausea is common and vomiting may occurHepatocellular injury is possible with ethionamide boostive. but is not commonVarious CNS effects have been reportedHypothyroidismgynecomastiaalopeciaimpotence also have been reported.
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ethionamide is taken twice daily, generally one tablet 250 mg in the daytime and 2 tablets 500 mg at night.